Projects / Programmes
Drug Delivery Microsystem
Code |
Science |
Field |
Subfield |
2.09.01 |
Engineering sciences and technologies |
Electronic components and technologies |
Materials for electronic components |
Code |
Science |
Field |
T150 |
Technological sciences |
Material technology |
Code |
Science |
Field |
2.02 |
Engineering and Technology |
Electrical engineering, Electronic engineering, Information engineering |
micromachining, wet etching, dry etching, DRIE, double-side photolithography, anodic bonding, hollow microneedle, microneedle array, micropump, PZT, dozing microsystems, MEMS, insulin delivery microsystem, biocompatibility
Researchers (14)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
11682 |
MSc Uroš Aljančič |
Electronic components and technologies |
Researcher |
2011 - 2014 |
206 |
2. |
01926 |
PhD Slavko Amon |
Electronic components and technologies |
Head |
2011 - 2014 |
473 |
3. |
31437 |
Nataša Artnak |
Electronic components and technologies |
Researcher |
2011 - 2014 |
0 |
4. |
01694 |
Zlatko Bele |
Electronic components and technologies |
Researcher |
2011 - 2014 |
17 |
5. |
31439 |
Vesna Bučar |
Electronic components and technologies |
Researcher |
2011 - 2014 |
0 |
6. |
17125 |
Matjaž Cvar |
|
Technical associate |
2011 - 2014 |
8 |
7. |
18372 |
PhD Andrej Janež |
Metabolic and hormonal disorders |
Researcher |
2011 - 2014 |
668 |
8. |
20186 |
PhD Matej Možek |
Electronic components and technologies |
Researcher |
2011 - 2014 |
270 |
9. |
30683 |
PhD Borut Pečar |
Electronic components and technologies |
Junior researcher |
2011 - 2013 |
118 |
10. |
05075 |
PhD Drago Resnik |
Electronic components and technologies |
Researcher |
2011 - 2014 |
261 |
11. |
28525 |
PhD Aleš Skvarča |
Metabolic and hormonal disorders |
Researcher |
2011 - 2014 |
142 |
12. |
01718 |
PhD Iztok Šorli |
Electronic components and technologies |
Researcher |
2011 - 2014 |
63 |
13. |
12151 |
PhD Vilma Urbančič-Rovan |
Metabolic and hormonal disorders |
Researcher |
2011 - 2014 |
219 |
14. |
04383 |
PhD Danilo Vrtačnik |
Electronic components and technologies |
Researcher |
2011 - 2014 |
309 |
Organisations (3)
Abstract
Microsystems for transdermal drug delivery (TDD) will be investigated, designed and realized, what represents the main result of the proposed applied research project. The developed microsystems will enable drug delivery by micropump and microneedle array directly through the stratum corneum layer of the patient’s skin.
Developed microsystem for transdermal drug delivery is actually a MEMS (micro-electro-mechanical system), and will be as such based on MEMS technologies. Such systems are commonly composed of microneedle array, micropump, microchannels, microreservoir, microfluidic connections, electron control unit and housing. In LMSE (Laboratory of microsensor structures and electronics, UL FE) exist appropriate knowledge, technologies and experience in the field of microstructures and microsystems. The proposed microsystem integration (all components integrated in one single substrate) will provide miniaturization, resulting in patient discretion and lower price. In addition, LMSE has strong background in the field of smart sensor electronics which will provide control and monitoring of the developed microsystem. Concepts of microsystem integration and of low energy consumption will therefore be introduced to enhance strongly the performance, as proposed in point 14 of this proposal.
The main advantages of direct transdermal drug delivery with proposed microsystem will be in accurate, programmable, continuous dosing and in exact positioning of delivery spot. Based on correct microneedle array design, this approach offers also the possibility of painless drug delivery and avoids possible implications in gastrointestinal tract met with pills.
Realized TDDS will bring advance in medical therapeutic treatments such as insulin dosing in case of diabetes, chemotherapies in oncology, anticoagulants in cardiovascular treatment, pain relievers in pain therapies and others.
Developed dozing microsystem, especially in the integrated version and supported by low power consumption control system as described in point 14 of this proposal, will provide an excellent platform for further medical research and also an opportunity for project industrial partner to join the world market.
Significance for science
The importance of obtained research results is in their applicative nature, but also as the contribution to the basic knowledge in various fields of MEMS structures such as material science, science of microtechnologies, microfluidics, numerical modeling, surface modification and chemical bonding, diffusion processes of substances in biological tissues and others. Performed research on these phenomena, revealing their basic mechanisms and establishing appropriate models, have led to new microstructure approaches, important for further progress in the field of microsystems. Obtained research results were published in appropriate scientific journals and international conferences.
Significance for the country
As evident from existing studies and forecasts on further development in microstructures science and technology, obtained research results will have also strong impact on progress of economy in Slovenia, such as productivity increase, competitiveness and economic growth, and key technologies advancement leading to improved products and processes with high added value. Dissemination of project results to students at university level and in specialized training courses, the inclusion of students and engineers in our experimental work and in other projects are most important project objectives, also from the aspect of staff high-tech training to meet the needs of our industrial partners. Research in the field of microstructures and microelectromechanical systems (MEMS), e.g. for biomedical applications has enabled the development of advanced microdosing technologies and methods. In addition, potential opportunities were identified for Slovenia key areas of the future, such as in the field of medicine, pharmaceutics, biotechnology, biochemistry, cosmetics and others. Upgraded knowledge will enable the fabrication of advanced MEMS with our own Slovenian technology. Successful interdisciplinary linking of knowledge between partners involved in the project represents a very strong basis for further work within the new cooperation frameworks. A significant breakthrough was also achieved in the area of communication with a wider range of potential users, through presentations and promotional materials, addressed to the institutions and companies in Slovenia as well as worldwide. Positive reply on these activities is already indicating possible new areas of cooperation.
Most important scientific results
Annual report
2011,
2012,
2013,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2011,
2012,
2013,
final report,
complete report on dLib.si