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Projects / Programmes source: ARIS

Drug Delivery Microsystem

Research activity

Code Science Field Subfield
2.09.01  Engineering sciences and technologies  Electronic components and technologies  Materials for electronic components 

Code Science Field
T150  Technological sciences  Material technology 

Code Science Field
2.02  Engineering and Technology  Electrical engineering, Electronic engineering, Information engineering 
Keywords
micromachining, wet etching, dry etching, DRIE, double-side photolithography, anodic bonding, hollow microneedle, microneedle array, micropump, PZT, dozing microsystems, MEMS, insulin delivery microsystem, biocompatibility
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11682  MSc Uroš Aljančič  Electronic components and technologies  Researcher  2011 - 2014  206 
2.  01926  PhD Slavko Amon  Electronic components and technologies  Head  2011 - 2014  473 
3.  31437  Nataša Artnak  Electronic components and technologies  Researcher  2011 - 2014 
4.  01694  Zlatko Bele  Electronic components and technologies  Researcher  2011 - 2014  17 
5.  31439  Vesna Bučar  Electronic components and technologies  Researcher  2011 - 2014 
6.  17125  Matjaž Cvar    Technical associate  2011 - 2014 
7.  18372  PhD Andrej Janež  Metabolic and hormonal disorders  Researcher  2011 - 2014  668 
8.  20186  PhD Matej Možek  Electronic components and technologies  Researcher  2011 - 2014  270 
9.  30683  PhD Borut Pečar  Electronic components and technologies  Junior researcher  2011 - 2013  118 
10.  05075  PhD Drago Resnik  Electronic components and technologies  Researcher  2011 - 2014  261 
11.  28525  PhD Aleš Skvarča  Metabolic and hormonal disorders  Researcher  2011 - 2014  142 
12.  01718  PhD Iztok Šorli  Electronic components and technologies  Researcher  2011 - 2014  63 
13.  12151  PhD Vilma Urbančič-Rovan  Metabolic and hormonal disorders  Researcher  2011 - 2014  219 
14.  04383  PhD Danilo Vrtačnik  Electronic components and technologies  Researcher  2011 - 2014  309 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,430 
2.  0341  MIKROIKS, microelectronics engineering, consulting and service  Ljubljana  5286646  70 
3.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  27,758 
Abstract
Microsystems for transdermal drug delivery (TDD) will be investigated, designed and realized, what represents the main result of the proposed applied research project. The developed microsystems will enable drug delivery by micropump and microneedle array directly through the stratum corneum layer of the patient’s skin.   Developed microsystem for transdermal drug delivery is actually a MEMS (micro-electro-mechanical system), and will be as such based on MEMS technologies. Such systems are commonly composed of microneedle array, micropump, microchannels, microreservoir, microfluidic connections, electron control unit and housing. In LMSE (Laboratory of microsensor structures and electronics, UL FE) exist appropriate knowledge, technologies and experience in the field of microstructures and microsystems. The proposed microsystem integration (all components integrated in one single substrate) will provide miniaturization, resulting in patient discretion and lower price. In addition, LMSE has strong background in the field of smart sensor electronics which will provide control and monitoring of the developed microsystem. Concepts of microsystem integration and of low energy consumption will therefore be introduced to enhance strongly the performance, as proposed in point 14 of this proposal.   The main advantages of direct transdermal drug delivery with proposed microsystem will be in accurate, programmable, continuous dosing and in exact positioning of delivery spot. Based on correct microneedle array design, this approach offers also the possibility of painless drug delivery and avoids possible implications in gastrointestinal tract met with pills.   Realized TDDS will bring advance in medical therapeutic treatments such as insulin dosing in case of diabetes, chemotherapies in oncology, anticoagulants in cardiovascular treatment, pain relievers in pain therapies and others.   Developed dozing microsystem, especially in the integrated version and supported by low power consumption control system as described in point 14 of this proposal, will provide an excellent platform for further medical research and also an opportunity for project industrial partner to join the world market.
Significance for science
The importance of obtained research results is in their applicative nature, but also as the contribution to the basic knowledge in various fields of MEMS structures such as material science, science of microtechnologies, microfluidics, numerical modeling, surface modification and chemical bonding, diffusion processes of substances in biological tissues and others. Performed research on these phenomena, revealing their basic mechanisms and establishing appropriate models, have led to new microstructure approaches, important for further progress in the field of microsystems. Obtained research results were published in appropriate scientific journals and international conferences.
Significance for the country
As evident from existing studies and forecasts on further development in microstructures science and technology, obtained research results will have also strong impact on progress of economy in Slovenia, such as productivity increase, competitiveness and economic growth, and key technologies advancement leading to improved products and processes with high added value. Dissemination of project results to students at university level and in specialized training courses, the inclusion of students and engineers in our experimental work and in other projects are most important project objectives, also from the aspect of staff high-tech training to meet the needs of our industrial partners. Research in the field of microstructures and microelectromechanical systems (MEMS), e.g. for biomedical applications has enabled the development of advanced microdosing technologies and methods. In addition, potential opportunities were identified for Slovenia key areas of the future, such as in the field of medicine, pharmaceutics, biotechnology, biochemistry, cosmetics and others. Upgraded knowledge will enable the fabrication of advanced MEMS with our own Slovenian technology. Successful interdisciplinary linking of knowledge between partners involved in the project represents a very strong basis for further work within the new cooperation frameworks. A significant breakthrough was also achieved in the area of communication with a wider range of potential users, through presentations and promotional materials, addressed to the institutions and companies in Slovenia as well as worldwide. Positive reply on these activities is already indicating possible new areas of cooperation.
Most important scientific results Annual report 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2011, 2012, 2013, final report, complete report on dLib.si
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