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Projects / Programmes source: ARIS

Atherosclerosis and thrombosis

Periods
Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
B530  Biomedical sciences  Cardiovascular system 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
atherosclerosis, thrombosis, etiopathogenesis, preclinical atherosclerosis, endothelial dysfunction, coagulation, systemic inflammatory markers, genetic polymorphisms, drug actions
Evaluation (rules)
source: COBISS
Researchers (43)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  37714  Metka Arh    Technical associate  2015 - 2017 
2.  21331  Simona Auman    Technical associate  2015 - 2018 
3.  32497  Ljubica Bavec    Technical associate  2015 - 2018 
4.  37325  Manca Behrič  Pharmacy  Technical associate  2018 
5.  07630  PhD Aleš Blinc  Cardiovascular system  Researcher  2015 - 2018  501 
6.  15637  PhD Mojca Božič Mijovski  Cardiovascular system  Researcher  2015 - 2018  217 
7.  36053  Anđa Duronjić    Technical associate  2015 - 2018 
8.  22347  PhD Barbara Eržen  Cardiovascular system  Researcher  2015 - 2018  76 
9.  11685  PhD Zlatko Fras  Cardiovascular system  Researcher  2015 - 2018  798 
10.  35642  Marko Jakopanec    Technical associate  2015 - 2018 
11.  33911  PhD Miodrag Janić  Cardiovascular system  Researcher  2017 - 2018  143 
12.  18395  Katja Janša-Trontelj    Technical associate  2015 - 2018 
13.  18396  Milojka Javoršek    Technical associate  2015 - 2018 
14.  38251  PhD Luka Jeraj  Cardiovascular system  Junior researcher  2016 - 2017  12 
15.  30830  PhD Mateja Kaja Ježovnik  Medical sciences  Researcher  2015 - 2016  181 
16.  24467  PhD Borut Jug  Cardiovascular system  Researcher  2015 - 2018  312 
17.  35982  Jelena Klepac    Technical associate  2015 - 2016 
18.  17729  Bojana Koščak    Technical associate  2015 - 2018 
19.  05965  PhD Matija Kozak  Cardiovascular system  Researcher  2015 - 2018  333 
20.  38795  Monika Kurtiš    Technical associate  2016 - 2018 
21.  28974  Nevenka Marinič    Technical associate  2015 - 2016 
22.  14642  PhD Alenka Mavri  Cardiovascular system  Researcher  2017 - 2018  222 
23.  18397  Anica Mencinger    Technical associate  2015 - 2016 
24.  21631  Biljana Milutinovič    Technical associate  2015 - 2016 
25.  31213  Jovanka Mohar    Technical associate  2015 - 2018 
26.  17732  Jana Mravlje    Technical associate  2015 - 2018 
27.  31962  PhD Jovana Nikolajević-Starčev.  Cardiovascular system  Researcher  2018  45 
28.  51294  PhD Marko Novaković  Cardiovascular system  Researcher  2018  49 
29.  24232  Agica Pacheco    Technical associate  2016 - 2018 
30.  17724  Andreja Pavlovič    Technical associate  2015 - 2016 
31.  24283  Mojca Perovšek    Technical associate  2015 - 2016 
32.  04548  PhD Pavel Poredoš  Cardiovascular system  Researcher  2015 - 2018  988 
33.  29298  Katja Sinkovič-Lukek    Technical associate  2015 - 2018 
34.  34574  PhD Ana Spirkoska  Cardiovascular system  Researcher  2015 - 2016  18 
35.  35983  Urška Stojanović    Technical associate  2015 - 2018 
36.  08094  PhD Mirza Šabovič  Cardiovascular system  Head  2015 - 2018  424 
37.  19345  PhD Miran Šebeštjen  Cardiovascular system  Researcher  2015 - 2018  272 
38.  32772  Marija Šparovec  Cardiovascular system  Technical associate  2015 - 2018 
39.  31412  Martina Špeh    Technical associate  2015 - 2018 
40.  21359  PhD Gregor Tratar  Cardiovascular system  Researcher  2015 - 2016  99 
41.  05888  PhD Nina Vene-Klun  Cardiovascular system  Researcher  2017 - 2018  170 
42.  22067  Karmen Zagorc    Technical associate  2015 - 2018 
43.  21885  Renata Žučko    Technical associate  2015 - 2018 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,959 
Abstract
Arterial atherosclerotic and venous thromboembolic disease represents one of the most common causes of death in developed countries. The etiopathogenesis of both disease is still not completely understood. Therefore, we would like to investigate the involvement of various risk factors in the pathogenesis of atherosclerosis and venous thrombosis. We plan to study changes in blood coagulation and fibrinolysis, as well as changes in the systemic inflammatory markers that are probably the common denominator of the pathogenesis of arterial and venous disease. Using non-invasive examination methods, like positron emission tomography, we aim to study the inflammatory changes of unstable atherosclerotic plaques that cause thromboembolic complications and compare them with systemic (circulating) inflammatory markers. Furthermore, we intend to evaluate the reliability and usefulness of the newer tests that allow the study of changes in the composition of the blood and to assess their predictive value in the development of atherothrombotic complications. We will continue to study changes in preclinical atherosclerosis. We will investigate vascular function and changes in the arterial wall in certain groups of patients, such as those with essential thrombocythemia and patients with various forms of coronary heart disease. We will search for safer and more effective therapeutic options that could give better results than currently available therapeutic approaches. We will explore why some drugs, particularly anti-platelet agents, are not effective in some patient groups with different atherosclerotic diseases and what is the impact of genetic polymorphism. We will study factors associated with the development of late complications in deep vein thrombosis and superficial thrombophlebitis. We expect that the findings of this research will contribute to a better understanding of the pathogenesis of atherosclerosis and thrombosis and thus lead to the possibility of choosing more efficient ways of identifying patients at risk and of prevention of the disease. Checking the mechanisms and effectiveness of drugs used in the prevention of heart disease will contribute to a more effective and individualized approach to treatment of these conditions.
Significance for science
The proposed research programme aims to answer open questions and uncertainties in relation to the development of the most common vascular diseases, atherosclerosis and thrombosis, and represents a scientific challenge whose resolution will probably have a major impact on the treatment of these patients. Our previous findings  have encouraged the interest of the international expert community. By studying the mechanisms of action and efficacy of drugs drugs used for the prevention and treatment of atherosclerosis, we will supplement existing knowledge of the pharmacotherapy of these diseases and thereby stimulate efforts to individualise pharmacotherapy and to ensure that mainly those drugs should be prescribed, for which there is direct evidence of positive effects on the cardiovascular system.
Significance for the country
Our aim is to answer some fundamental questions regarding the occurrence of cardiovascular disease and to assess the possibilities of the most effective therapeutic approaches; this will contribute to a better and more rational choice of treatment for those cardiovascular patients in Slovenia who have the highest morbidity and mortality. The research findings and knowledge that we gain through these scientific research activities will be successfully distributed at Slovenian and international level. In this way we promote not only Slovenian science but also our country. Based on the results achieved so far our group has a high reputation internationally. Members of our research group present their work at the international scientific congresses and are invited to take an active part as members of the most important European vascular associations. The Head of our research group with co-workers had the privilege and honour to be the host of several important international meetings and conferences. Members of our research group present the results of our research activities as invited speakers at European and world congresses and thereby promote Slovenian science.
Most important scientific results Annual report 2015, 2016, 2017, final report
Most important socioeconomically and culturally relevant results Annual report 2015, 2016, 2017, final report
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