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Projects / Programmes source: ARRS

Interakcije Hg in Cd z lipoproteini, liposomskimi membranami, selenom in metalotioneini (Slovene)

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
P360  Natural sciences and mathematics  Inorganic chemistry 
Keywords
Hg, Cd, Se, metallothioneins, lipoproteins, liposome membranes, interactions
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  10582  PhD Ingrid Falnoga  Medical sciences  Researcher  1999 - 2001  335 
2.  05027  PhD Milena Horvat  Natural sciences and mathematics  Researcher  1999 - 2001  1,820 
3.  00412  PhD Igor Križaj  Natural sciences and mathematics  Researcher  1999 - 2001  698 
4.  18288  PhD Martina Logar  Natural sciences and mathematics  Researcher  1999 - 2001  155 
5.  00393  PhD Milan Valter Schara  Natural sciences and mathematics  Researcher  1999 - 2001  343 
6.  01352  PhD Peter Stegnar  Natural sciences and mathematics  Principal Researcher  1999 - 2001  275 
7.  01873  PhD Vekoslava Stibilj  Natural sciences and mathematics  Researcher  1999 - 2001  686 
8.  01411  PhD Zdenka Šlejkovec  Natural sciences and mathematics  Researcher  1999 - 2001  237 
9.  13786  Borut Štefanič  Medical sciences  Researcher  1999 - 2001  61 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  85,680 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  45,192 
Abstract
Cadmium and mercury ions can act as neurotoxins and are probably involved in the pathogenesis of some brain dysfunctions like Alzheimer''s disease and age senility. The investigation will be focused on interactions of inorganic mercury with biological macromolecules (lipoproteins, liposomes) with respect to the induced changes in their structural organization and the involvement of mercury in lipid peroxidation. In human tissue samples (thyroid, brain tissues) with elevated levels of toxic trace elements (Hg, Cd) the study will be concentrate on the cellular distribution of these elements, their binding to low molecular weight protective proteins, i.e. metallothioneins and selenium coaccumulation.
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