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Projects / Programmes source: ARIS

Interakcije Hg in Cd z lipoproteini, liposomskimi membranami, selenom in metalotioneini (Slovene)

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
P360  Natural sciences and mathematics  Inorganic chemistry 
Keywords
Hg, Cd, Se, metallothioneins, lipoproteins, liposome membranes, interactions
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publications
1.  10582  PhD Ingrid Falnoga  Neurobiology  Researcher  1999 - 2001  344 
2.  05027  PhD Milena Horvat  Chemistry  Researcher  1999 - 2001  1,887 
3.  00412  PhD Igor Križaj  Biochemistry and molecular biology  Researcher  1999 - 2001  726 
4.  18288  PhD Martina Logar  Chemistry  Researcher  1999 - 2001  157 
5.  00393  PhD Milan Valter Schara  Physics  Researcher  1999 - 2001  343 
6.  01352  PhD Peter Stegnar  Control and care of the environment  Head  1999 - 2001  275 
7.  01873  PhD Vekoslava Stibilj  Chemistry  Researcher  1999 - 2001  687 
8.  01411  PhD Zdenka Šlejkovec  Chemistry  Researcher  1999 - 2001  240 
9.  13786  Borut Štefanič  Neurobiology  Researcher  1999 - 2001  61 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,724 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,238 
Abstract
Cadmium and mercury ions can act as neurotoxins and are probably involved in the pathogenesis of some brain dysfunctions like Alzheimer''s disease and age senility. The investigation will be focused on interactions of inorganic mercury with biological macromolecules (lipoproteins, liposomes) with respect to the induced changes in their structural organization and the involvement of mercury in lipid peroxidation. In human tissue samples (thyroid, brain tissues) with elevated levels of toxic trace elements (Hg, Cd) the study will be concentrate on the cellular distribution of these elements, their binding to low molecular weight protective proteins, i.e. metallothioneins and selenium coaccumulation.
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