Projects / Programmes
January 1, 2020
- December 31, 2027
| Code |
Science |
Field |
Subfield |
| 3.02.00 |
Medical sciences |
Stomatology |
|
| 3.03.00 |
Medical sciences |
Neurobiology |
|
| Code |
Science |
Field |
| B000 |
Biomedical sciences |
|
| Code |
Science |
Field |
| 3.02 |
Medical and Health Sciences |
Clinical medicine |
| 3.01 |
Medical and Health Sciences |
Basic medicine |
periodontal disease, 3D imaging, growth and development, diabetes, bone, obesity, minimally invasive treatment, orthodontics, cleft, congenital malformations, computer-aided diagnostics, CBCT, lasers
Data for the last 5 years (citations for the last 10 years) on
April 24, 2024;
A3 for period
2018-2022
| Database |
Linked records |
Citations |
Pure citations |
Average pure citations |
| WoS |
248 |
2,703 |
2,400 |
9.68 |
| Scopus |
226 |
3,238 |
2,900 |
12.83 |
Researchers (13)
Organisations (2)
Abstract
Our research programme will focus on
(a) 3D computer based evaluation and diagnosis,
Recently, 3D scanning methods for capture of oral tissues are increasingly used in prosthodontics with precision of 0.1 mm or even less. Utilization of such approach would provide increased objectivity and accuracy of measurements. The fusion of complementary modalities, such as CBCT, and MRI, further expand the possibilities, as non-visible structure could also be acquired. Fusion of obtained data would provide qualitative and quantitative evaluation of changes of time related morphological changes in maxillofacial region associated with growth and development, disease and healing dynamics in soft and mineralized tissues
(b) Periodontal disease: relationship between systemic diseases and minimally invasive treatment, and
Periodontal microbiology research has moved from species to strains. In our research we’ll examine the importance of the presence, virulence and antibiotic resistance of periodontal pathogens in chronic periodontitis in Slovenian population
Periodontitis affects the onset and progression of cardiovascular disease, which affects most people as chronic inflammatory diseases. Research suggests several possible inflammatory mechanisms for the association of periodontal disease and cardiovascular disease, diabetes, and bone remodelation. In our research we’ll focus on study of relationship between periodontal disease and diabetes and metabolic syndrome.
Minimally invasive treatment will can be achieved by the use of lasers. We will evaluate the effect of double activation of RB dye on the bacterial flora in the periodontal pocket, and the gain of clinical attachment and inflammatory markers.
(c) Cleft therapy: optimization of timing of surgical procedures aiming to maximize the function and appearance
We will evaluation the growth of alveolar bone in the cleft region in the pre-pubertal period in the patients with cleft where early secondary gingivo-alveolo-plasty was performed, aiming to optimize timing of surgical reconstruction procedure.
Understanding of the pathological processes in the oral cavity at all levels, from the molecular, cellular, tissue, to the human being as a whole, in all dimensions, and the possibilities of new treatments will be the basis for raising the oral health of the inhabitants of Republic of Slovenia. The involvement of researchers in professional and organizational dental activities, pedagogical work at undergraduate and postgraduate levels, and other social activities is a guarantee for the transfer of research results to the rise in the level of dental care in the Republic of Slovenia.
Significance for science
The proposed research program will contribute significantly to the body of knowledge on the causes and course of periodontal disease and the importance of long-term chronic infection of periodontal tissues on the development of certain systemic diseases such as cardiovascular disease and diabetes. The program will assess the natural progression of inflammatory periodontal tissues in the population that we follow for 30 years and established risk factors for the progression of periodontal disease. The proposed program will try a local oral hygiene treatment to determine whether this treatment contributes to the reduction of recurrence of cardiovascular complications and improve the metabolic status of the diabetic patient. The program will also examine the periodontal tissue condition in pregnant women with type 1 diabetes and the impact of periodontal disease on the possible complications during pregnancy and preterm delivery. We also intend to determine the effect of orthodontic treatment in diabetics on the metabolism of alveolar bone. An important contribution to science of the study will be evaluation of the impact of chronic inflammation of the periodontal tissues to the level of glycated hemoglobin in patients without diabetes.
Majority of research methods in dental research, such as microbiology, genetics, and biochemistry has undergone constant development. However, the clinical evaluation of patients and experimental animals is often based on visual observation and measurement with periodontal probe, basically a method, that is over 60 years old. Such an approach is simply not in line with above mentioned methods and early changes, not noticeable to human eye remain undetected. Although the use of 3D imaging is well established in clinical practice, the image evaluation and measurements are still using only 1D or 2D parameters. The full potential of real 3d evaluation has yet to be developed. 3D evaluation parameters, developed by our group, will allow detection of minute changes. This would enable faster, more reliable and more precise clinical measurement in all areas of dentistry. Furthermore, such an approach has a great potential in clinical use for detection of early changes, indicating the need for prevention or minimally invasive treatment.
G
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Significance for the country
Understanding of the pathological processes in the oral cavity at all levels, from the molecular, cellular, tissue, to the human being as a whole, in all dimensions, and the possibilities of new treatments will be the basis for raising the oral health of the inhabitants of Republic of Slovenia. The involvement of researchers in professional and organizational dental activities, pedagogical work at undergraduate and postgraduate levels, and other social activities is a guarantee for the transfer of research results to the rise in the level of dental care in the Republic of Slovenia.
The proposed research program will contribute new insights on the relationship between periodontal disease and certain systemic diseases and conditions among the population of Slovenia. Pandemic proportions of periodontal disease in Slovenia and findings of the impact of gingival inflammation on systemic inflammatory immune response of the organism will be the starting point for priority for treatment of high-risk population groups and planning specialist network of periodontists and dental hygienists in Slovenia. The research results will also be important in the pedagogical training of dentists and doctors at undergraduate and postgraduate level. In the context of the proposed program already two young researchers defended Ph.D. thesis and in the next period another doctoral thesis will be performed by young researcher.
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