Projects / Programmes
January 1, 2009
- December 31, 2014
| Code |
Science |
Field |
Subfield |
| 3.02.00 |
Medical sciences |
Stomatology |
|
| Code |
Science |
Field |
| B730 |
Biomedical sciences |
Odontology, stomatology |
| Code |
Science |
Field |
| 3.02 |
Medical and Health Sciences |
Clinical medicine |
periodontal medicine, periodontal disease, diabetes, cardiovascular disease, pulomonary disease, artritis, stres, MRI, subtraction radiography, antioxidants, lasers, Papillon-Lefevre sy, orthodontics, NO,epidemiology, oral health, children, adolescents
Researchers (14)
Organisations (1)
Abstract
In research program the natural progression of periodontal disease in 20 year period and influence of the long standing chronic infection in periodontal tissues on the development of some systemic diseases such as cardiovascular disease, diabetes, arthritis and pneumonia will be studied. In the frame of the research program the evaluation of the periodontal wound and the influence of periodontal treatment on improvement of cardiovascular disease and diabetes will be evaluated. The prevalence of caries and periodontal disease in patients with special needs and role of NO on bone remodeling during the orthodontic treatment will be studied. In addition the role of the gene for cathepsin C in Papillon-Lefevre syndrom and influence of periodontal inflammation on activation of hypothalamo-hypophise-suprarenal axis will be studied. In therapeutic part of the program the use of pulse Er-YAG laser for periodontal surgery and the use of local subgingival delivery of antioxidant enzymes for treatment of periodontal inflammation will be evaluated.
Significance for science
As part of the research program, we have developed a new method for the evaluation of inflammatory periodontal burden and periodontal wound bleeding in patients with periodontal disease. The original method makes it possible on the basis of the size of inflammatory periodontal burden estimate the level of serum C-reactive protein, which is an indicator of systemic inflammation. So we got a method that quantifies the impact of periodontal disease on systemic inflammation and possible risk for cardiovascular complications. The link between inflammation of periodontal tissues of certain systemic diseases were observed in randomly selected patients referred to periodontist and found that as many as 62% reported the presence of one or more systemic disease and that 25% of them take different drugs. The relationship between diabetes and periodontal disease were studied in patients with type 1 diabetes and found that the presence of two specific microorganisms in subgingival plaques were associated with significantly higher serum serum levels of glycated hemoglobin. In the field of diagnostics of gingival inflammation it was shown that magnetic resonance imaging can trace the improvement in clinical periodontal parameters in patients after periodontal therapy. In studies on experimental animals it was found that in experimental periodontitis in rats nerve growth factor contributes to the resorption of the alveolar bone, and that the treatment with the neutralization of nerve growth factor contributes to a reduction in alveolar bone resorption.
Significance for the country
The research program has contributed new insights on the relationship between certain systemic diseases and periodontal disease among the population of the Republic of Slovenia. New method of assessing inflammatory periodontal burden will allow the patients in the clinic directly measure the impact of periodontal inflammation on systemic inflammation and possible risk of developing cardiovascular disease. The results of the research status of periodontal tissues in diabetic patients suggest the need for priority dental and periodontal treatment of diabetics. The results of the research program will also affect the education of dentists and physicians at the undergraduate and graduate levels. Pandemic dimension of periodontal disease among the population of Slovenia will affect the design of a network of periodontisst and oral hygienists. In the context of the program one young researcher finished PhD thesis and in the coming period a doctoral thesis will be carried out another young researcher.
Most important scientific results
Annual report
2009,
2010,
2011,
2012,
2013,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2012,
2013,
final report,
complete report on dLib.si
