Projects / Programmes
January 1, 2015
- December 31, 2019
| Code |
Science |
Field |
Subfield |
| 3.02.00 |
Medical sciences |
Stomatology |
|
| Code |
Science |
Field |
| B730 |
Biomedical sciences |
Odontology, stomatology |
| Code |
Science |
Field |
| 3.02 |
Medical and Health Sciences |
Clinical medicine |
Periodontal disease, epidemiological survey, periodontal wound, periodontal inflammatory burden, cardiovascular diseases, diabetes, pregnancy, orthodontic tooth movement, healing of bone defects, magnetic resonace, gene polymorphysms, neurogenic inflammation, endodontic treatment
Researchers (11)
Organisations (1)
Abstract
In the research program we will in a group of 247 inhabitants of Ljubljana assess changes in the status of periodontal tissue 30 years after the initial examination and determine risk factors for the progression of periodontal disease. We will also assess changes in the size of periodontal wounds and inflammatory periodontal burden in the 10 year period. In 30 subjects with the highest periodontal inflammatory burden we will measure C-reactive protein before and after oral hygiene phase of periodontal treatment and a decrease of the inflammatory mediator in serum. In the program, we intend to clarify the specificity of the major periodontal bacteria in dental plaque in Slovenian patients with chronic periodontitis . We will also observe the presence of periodontal pathogenic bacteria and protozoa in plaque in patients with diabetes mellitus type 1 and 2 and in pregnant women with type 1 diabetes mellitus We will examine the potential impact of long-term chronic inflammation of the periodontal tissues to the level of glycated hemoglobin in patients with chronic periodontitis and without diabetes . In the course of the pathogenesis of inflammatory periodontal diseases we will study the expression of NGF and BDNF nevrotropins in gingiva of patients with chronic periodontitis. In the continuing search for new diagnostic methods to diagnose the periodontal diseases, we will continue to research the usefulness of MRI in periodontology. On models of cell suspensions we will study relaxation processes of nuclear spins of protons and indirect MR signal intensity of the images.
In the intervening part of the research we will examine the impact of oral hygiene treatment to improve the condition of periodontal tissue in patients with aggressive periodotitis, in patients recovering from myocardial infarction and in patients with diabetes. Bone metabolism and healing of calvaria subcritical size defect in rats will be assessed in female rats with osteoporosis induced by ovariektomy. We will examine the possibilities of orthodontic tooth movements in patients with type 1 diabetes where osteoporosis is one of the major complications . The study will also examine whether polymorphisms of genes for certain inflammatory mediators influence the healing success of periapical bone defects by endodontic treatment.
Significance for science
The proposed research program will contribute significantly to the body of knowledge on the causes and course of periodontal disease and the importance of long-term chronic infection of periodontal tissues on the development of certain systemic diseases such as cardiovascular disease and diabetes. The program will assess the natural progression of inflammatory periodontal tissues in the population that we follow for 30 years and established risk factors for the progression of periodontal disease. In previous studies we have confirmed the hypothesis that the size of the periodontal bleeding wounds and inflammatory periodontal burden impact on the indicators of systemic inflammation such as C - reactive protein. The proposed program will try a local oral hygiene treatment to determine whether this treatment contributes to the reduction of recurrence of cardiovascular complications and improve the metabolic status of the diabetic patient. The program will also examine the periodontal tissue condition in pregnant women with type 1 diabetes and the impact of periodontal disease on the possible complications during pregnancy and preterm delivery. We also intend to determine the effect of orthodontic treatment in diabetics on the metabolism of alveolar bone. An important contribution to science of the study will be evaluation of the impact of chronic inflammation of the periodontal tissues to the level of glycated hemoglobin in patients without diabetes. The proposed program also intend to examine the impact of genetic polymorphisms of interleukin 1 on the success of healing of periapical bone defects by endodontic treatment.
Significance for the country
The proposed research program will contribute new insights on the relationship between periodontal disease and certain systemic diseases and conditions among the population of Slovenia. Pandemic proportions of periodontal disease in Slovenia and findings of the impact of gingival inflammation on systemic inflammatory immune response of the organism will be the starting point for priority for treatment of high-risk population groups and planning specialist network of periodontists and dental hygienists in Slovenia. The research results will also be important in the pedagogical training of dentists and doctors at undergraduate and postgraduate level. In the context of the proposed program already two young researchers defended Ph.D. thesis and in the next period another doctoral thesis will be performed by young researcher.
Most important scientific results
Annual report
2015,
interim report,
final report
Most important socioeconomically and culturally relevant results
Annual report
2015,
interim report,
final report
