Projects / Programmes
FLORFENICOL, LASALOCID AND COUMAPHOS USE IN ANIMAL HEALTH CARE, FROM THE ASPECT OF ENVIRONMENT PROTECTION
| Code |
Science |
Field |
Subfield |
| 4.04.03 |
Biotechnical sciences |
Veterinarian medicine |
Therapy and health prevention of animals |
| Code |
Science |
Field |
| B740 |
Biomedical sciences |
Pharmacological sciences, pharmacognosy, pharmacy, toxicology |
| Code |
Science |
Field |
| 4.03 |
Agricultural and Veterinary Sciences |
Veterinary science |
veterinary medicine,drugs, pesticides, florfenicol, lasalocid, coumaphos, environment
Researchers (17)
Organisations (1)
Abstract
The proposed research project is aimed at qualitatively and quantitatively evaluating the use of some antimicrobial and antiparasitic pharmaceuticals and pesticides used in veterinary medicine, and determining the impacts these substances may have on the environment and human health. We will focus on three different substances representing different aspects of animal healthcare and different routes of exposure: the antibiotic florfenicol for treating infections in farmed fish, the ionophore antibiotic lasalocid for treatment and prevention of coccidiosis in broilers, and the organophosphate insecticide coumaphos used to control varroa mites in honey bee colonies.
The research on florfenicol will be focused on determining potential residues of florfenicol in seawater, sediment and fish tissues. During and after administration of florfenicol at one of the Slovene fish farms, we will monitor its concentrations in the environment and free-living fish at different distances from the farm.
Our work on lasalocid will be divided into two parts: performing ecotoxicological tests on non-target soil organisms; and studying the degradation of lasalocid in manure from treated broiler chickens. We will use standardised ecotoxicological tests to ascertain the sensitivity of soil organisms to the presence of lasalocid in soil and by measuring its half-life in manure, we will be able to determine the concentrations that could be expected in soil where contaminated manure is used under different scenarios (no storing, storage and composting). The obtained results will provide essential information for deducing the environmental risk associated with the use of lasalocid-contaminated manure on farmlands. We will provide recommendations on the safe use of manure containing lasalocid.
Our work on the organophosphate pesticide coumaphos will provide information on coumaphos residues in bee brood, bee produce and feed at different levels of coumaphos introduced. We will also study the effects of different levels of coumaphos on the development of bees and their brood compared to the control group. The findings will be used for planning varroa exterminations in the future. Furthermore, our work on coumaphos will also focus on the effects of long-term exposure to low levels of coumaphos on the development of the nervous system in mammalian embryos.
Significance for science
Results of the research allow preparing the guidelines for the fertilization of agricultural land with manure originating from broiler farms where chickens were treated with monensin or lasalocid. Experiment including bees revealed the ineffectiveness of amitraz in the treatment of varroasis, which shows the potential development of resistance to amitraz what should be taken into account in the annual selection of acaricides.
Significance for the country
Results of the research allow preparing the guidelines for the fertilization of agricultural land with manure originating from broiler farms where chickens were treated with monensin or lasalocid. Experiment including bees revealed the ineffectiveness of amitraz in the treatment of varroasis, which shows the potential development of resistance to amitraz what should be taken into account in the annual selection of acaricides.
Most important scientific results
Annual report
2011,
2013,
final report
Most important socioeconomically and culturally relevant results
Annual report
2013,
final report
