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Projects / Programmes source: ARIS

Impact of chromium and iron species interaction on yeast cell performance

Research activity

Code Science Field Subfield
4.06.00  Biotechnical sciences  Biotechnology   

Code Science Field
T490  Technological sciences  Biotechnology 
Keywords
yeasts, chromium, iron, interaction, stress, metabolism, physiology, toxicity
Evaluation (rules)
source: COBISS
Researchers (18)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18332  PhD Neža Čadež  Biotechnology  Researcher  2004 - 2007  322 
2.  20920  Urška Debelak    Technical associate  2004 - 2007 
3.  21392  PhD Štefan Fujs  Biotechnology  Researcher  2004 - 2007  87 
4.  12315  PhD Ester Heath  Control and care of the environment  Researcher  2004 - 2007  603 
5.  18511  PhD Polona Jamnik  Biotechnology  Researcher  2004 - 2007  904 
6.  21462  PhD Špelca Jenko  Pharmacy  Researcher  2004 - 2006  18 
7.  04351  PhD Bogdan Kralj  Chemistry  Researcher  2004 - 2007  131 
8.  22779  Vlasta Medvešek    Technical associate  2004 - 2005 
9.  08314  PhD Radmila Milačič  Control and care of the environment  Researcher  2004 - 2007  800 
10.  15618  PhD Maja Paš  Biotechnology  Researcher  2004 - 2007  103 
11.  08946  Silva Perko    Technical associate  2004 - 2007  51 
12.  23172  PhD Borut Poljšak  Public health (occupational safety)  Researcher  2004 - 2007  284 
13.  18126  PhD Katja Povhe Jemec  Biotechnology  Researcher  2004 - 2006  61 
14.  04001  PhD Peter Raspor  Microbiology and immunology  Head  2004 - 2007  1,898 
15.  18359  PhD Janez Ščančar  Control and care of the environment  Researcher  2004 - 2007  677 
16.  19506  Matej Šergan    Technical associate  2004 - 2007 
17.  01411  PhD Zdenka Šlejkovec  Chemistry  Researcher  2004 - 2007  240 
18.  03950  PhD Dušan Žigon  Chemistry  Researcher  2004 - 2007  168 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,624 
2.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,240 
Abstract
Mineral elements are needed for proper functioning of all living cells. Interaction of essential elements can lead to deficiency and toxicity of particular element to cell metabolism. Chromium and iron are essential elements, which have very important role in cell metabolism. Chromium is important trace element in carbohydrate metabolism, essential for maintenance of normal glucose tolerance in human, while the essential contribution of iron is connected with electron transport in respiratory chain and redox reactions in the cell. Yeasts are often used as a biological model comparable to the higher eucariotic organisms. For this proposal yeasts were selected as a model organism for elucidation of poorly understood field of interaction effects between chromium and iron. It is known that high concentration of chromium in the cell can induce symptoms of iron deficiency and oxidative stress response. Iron and chromium species belong to redox active metals, which play an important role in generation of reactive oxygen species in the cell, causing consecutive changes on the protein, DNA and lipid level. Generally, high concentrations of both essential elements in the cell could have toxic effects. Goal of the basic research, which involves yeast as model organism, is focused on elucidation and clarification of interaction effect of chromium and iron species on metabolism of particular essential element in yeast cell, yeast cell response and physiology, processes of metal binding and toxicity in the yeast cell. The results of the project are directly relevant for food and farmaceutical industry (functional food, nutraceuticals), environmental issues (toxicity), basic science (elucidation of Cr-Fe interaction), etc.
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