Projects / Programmes
Impact of chromium and iron species interaction on yeast cell performance
| Code |
Science |
Field |
Subfield |
| 4.06.00 |
Biotechnical sciences |
Biotechnology |
|
| Code |
Science |
Field |
| T490 |
Technological sciences |
Biotechnology |
yeasts, chromium, iron, interaction, stress, metabolism, physiology, toxicity
Researchers (18)
Organisations (2)
Abstract
Mineral elements are needed for proper functioning of all living cells. Interaction of essential elements can lead to deficiency and toxicity of particular element to cell metabolism. Chromium and iron are essential elements, which have very important role in cell metabolism. Chromium is important trace element in carbohydrate metabolism, essential for maintenance of normal glucose tolerance in human, while the essential contribution of iron is connected with electron transport in respiratory chain and redox reactions in the cell. Yeasts are often used as a biological model comparable to the higher eucariotic organisms. For this proposal yeasts were selected as a model organism for elucidation of poorly understood field of interaction effects between chromium and iron. It is known that high concentration of chromium in the cell can induce symptoms of iron deficiency and oxidative stress response. Iron and chromium species belong to redox active metals, which play an important role in generation of reactive oxygen species in the cell, causing consecutive changes on the protein, DNA and lipid level. Generally, high concentrations of both essential elements in the cell could have toxic effects. Goal of the basic research, which involves yeast as model organism, is focused on elucidation and clarification of interaction effect of chromium and iron species on metabolism of particular essential element in yeast cell, yeast cell response and physiology, processes of metal binding and toxicity in the yeast cell. The results of the project are directly relevant for food and farmaceutical industry (functional food, nutraceuticals), environmental issues (toxicity), basic science (elucidation of Cr-Fe interaction), etc.
