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Projects / Programmes source: ARRS

Preučevanje biosinteze eritromicina s proteomskimi orodji (Slovene)

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Research activity

Code Science Field Subfield
4.06.04  Biotechnical sciences  Biotechnology  Microbe biotechnology 

Code Science Field
2.09  Engineering and Technology  Industrial biotechnology 
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publications
1.  18332  PhD Neža Čadež  Biotechnology  Researcher  2009  306 
2.  32502  PhD Dušan Goranovič  Biotechnology  Researcher  2010 - 2012  30 
3.  25519  PhD Jaka Horvat  Biotechnology  Researcher  2009 - 2012  49 
4.  32607  PhD Katja Istenič  Interdisciplinary research  Junior researcher  2011 - 2012  35 
5.  18511  PhD Polona Jamnik  Biotechnology  Principal Researcher  2009 - 2012  881 
6.  23483  PhD Enej Kuščer  Biotechnology  Researcher  2009 - 2012  36 
7.  21244  PhD Jan Mavri  Pharmacy  Researcher  2009  57 
8.  13542  PhD Hrvoje Petković  Biotechnology  Researcher  2009 - 2010  289 
9.  04001  PhD Peter Raspor  Microbiology and immunology  Researcher  2009  1,877 
10.  19506  Matej Šergan    Technician  2010  0 
11.  31211  Milena Žabkar    Technician  2010 - 2012  0 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  64,462 
2.  2592  ACIES BIO, biotehnološke raziskave in razvoj, d.o.o. (Slovene)  Ljubljana  2226391  472 
Significance for science
Biosynthesis of natural polyketides, including numerous antibiotics has been studied intensively for more than 40 years. Despite of that mechanisms of of biosynthesis of several compounds remain poorly understood. High-producing strains used in industrial bioprocesses are result of laborious selections, which can last for number of years or even decades. Different random mutagenesis approaches have been applied, such as chemical and UV mutagenesis. Unfortunatelly these approaches do not provide insight into mechanisms that govern such raise in metabolites production, and offer no useful information for the rational targeted strain improvement approaches. In the project a new innovative methodological approach was introduced for proteome comparison of a wild type and a high-producing industrial strain. Such systemic approaches to analysis of metabolic pathways are still very limited in the scientific literature which make the research project on systemic proteomic approach a very important contribution to the systemic biology and holistic understanding of key drivers in metabolism of also other industrial high-producing strains. In the scope of this project we have established that the proteomic approach enables the identification of key features of industrial strains, which can be successfully used in further development of industrial strains.
Significance for the country
The project was a continuation of already fruitful collaboration between the Biotechnical faculty of the University of Ljubljana and biotechnological company Acies Bio and at the same time a great start point for new shared applications. It enabled a transfer of knowledge and thus integrated the Slovenian academic and industrial sector. On the basis of the project Acies Bio began using proteomic methods in improving industrial strains, which can significantly increase long-term competitiveness of the company in international markets contract research. The project was also a great opportunity for educating and training of young researchers from the Biotechnical faculty as well as from Acies Bio. Two students of biotechnology were involved in the project work in the frame of their MSc thesis and two Ph.D. students will defend their Ph.D. thesis in the coming years.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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