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Projects / Programmes source: ARIS

Endocrine, immune and enzyme responses in healthy and sick animals

Periods
Research activity

Code Science Field Subfield
4.04.00  Biotechnical sciences  Veterinarian medicine   

Code Science Field
B750  Biomedical sciences  Veterinary medicine: surgery, physiology, pathology, clinical studies 

Code Science Field
4.03  Agricultural and Veterinary Sciences  Veterinary science 
Keywords
veterinary medicine; basic research; translational research; clinical trials; morphology; genetics; neurobiology; endocrinology; physiology; pharmacology; toxicology; oxidative stress; reproduction; oncology; dentistry; cardiology; stem cells; immunotherapy
Evaluation (rules)
source: COBISS
Points
12,178.09
A''
356.67
A'
5,739.84
A1/2
6,907.72
CI10
6,995
CImax
122
h10
34
A1
41.13
A3
41.93
Data for the last 5 years (citations for the last 10 years) on April 18, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender , archive )
Database Linked records Citations Pure citations Average pure citations
WoS  752  10,279  8,953  11.91 
Scopus  755  11,928  10,465  13.86 
Researchers (66)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  39086  PhD Neža Adamič  Veterinarian medicine  Technical associate  2019 - 2022  10 
2.  15595  Katarina Babnik    Technical associate  2020 - 2024 
3.  55379  Sanja Bogićević    Technical associate  2021 - 2022  19 
4.  50219  PhD Jana Brankovič  Veterinarian medicine  Researcher  2020 - 2024  48 
5.  55732  Martina Cimerman  Veterinarian medicine  Junior researcher  2021 - 2024 
6.  17572  PhD Marko Cotman  Veterinarian medicine  Researcher  2019 - 2024  119 
7.  33148  PhD Maša Čater  Biotechnology  Researcher  2019  109 
8.  10445  PhD Nina Čebulj-Kadunc  Veterinarian medicine  Researcher  2019 - 2024  204 
9.  56948  Maša Čok  Veterinarian medicine  Junior researcher  2022 - 2024 
10.  18128  Magdalena Dobravec    Technical associate  2020 - 2024 
11.  10395  PhD Aleksandra Domanjko Petrič  Veterinarian medicine  Researcher  2019 - 2024  262 
12.  18122  Boštjan Drolc  Veterinarian medicine  Technical associate  2020 - 2024  10 
13.  21400  PhD Vladimira Erjavec  Veterinarian medicine  Researcher  2019 - 2024  158 
14.  09149  PhD Gregor Fazarinc  Veterinarian medicine  Researcher  2019 - 2024  203 
15.  57998  Petra Ferjan  Veterinarian medicine  Junior researcher  2023 - 2024 
16.  12449  PhD Robert Frangež  Veterinarian medicine  Researcher  2019 - 2024  280 
17.  54725  Jernej Gačnikar  Veterinarian medicine  Junior researcher  2020 - 2024 
18.  24348  PhD Neža Grgurevič  Veterinarian medicine  Researcher  2019 - 2024  58 
19.  21699  Aleksander Jenko    Technical associate  2020 - 2024 
20.  10913  PhD Vesna Kadunc Kos  Veterinarian medicine  Researcher  2019 - 2024  84 
21.  53480  Anja Kalin  Veterinarian medicine  Junior researcher  2019 - 2021 
22.  21230  PhD Primož Klinc  Veterinarian medicine  Researcher  2019 - 2024  107 
23.  09654  PhD Silvestra Kobal  Veterinarian medicine  Retired researcher  2019 - 2024  260 
24.  34335  PhD Saša Koprivec  Veterinarian medicine  Researcher  2019 - 2021  23 
25.  07439  PhD Marjan Kosec  Veterinarian medicine  Retired researcher  2019  387 
26.  56945  Jelena Kotiščak  Veterinarian medicine  Junior researcher  2022 - 2024 
27.  14194  PhD Tina Kotnik  Veterinarian medicine  Researcher  2019 - 2024  141 
28.  20042  PhD Petra Kramarič  Veterinarian medicine  Researcher  2019 - 2024  59 
29.  15198  PhD Peter Kruljc  Veterinarian medicine  Researcher  2019 - 2024  130 
30.  23485  PhD Valentina Kubale Dvojmoč  Veterinarian medicine  Researcher  2019 - 2024  272 
31.  21402  PhD Barbara Lukanc  Veterinarian medicine  Researcher  2019 - 2024  68 
32.  13330  PhD Gregor Majdič  Veterinarian medicine  Researcher  2019 - 2021  577 
33.  50524  PhD Maša Mavri  Veterinarian medicine  Junior researcher  2019 - 2023  32 
34.  39087  PhD Nina Milevoj  Veterinarian medicine  Researcher  2019 - 2022  54 
35.  52021  Patrik Milić  Medical sciences  Technical associate  2023 - 2024 
36.  10253  PhD Janko Mrkun  Veterinarian medicine  Researcher  2019 - 2024  270 
37.  25587  PhD Ana Nemec  Veterinarian medicine  Researcher  2019 - 2024  328 
38.  16308  PhD Alenka Nemec Svete  Veterinarian medicine  Researcher  2019 - 2024  215 
39.  53481  PhD Matic Pavlica  Biotechnical sciences  Junior researcher  2019 - 2024 
40.  07516  PhD Zlatko Pavlica  Veterinarian medicine  Retired researcher  2019 - 2024  376 
41.  24507  PhD Darja Pavlin  Veterinarian medicine  Researcher  2019 - 2024  161 
42.  55730  Špela Petročnik  Veterinarian medicine  Junior researcher  2021 - 2024 
43.  33619  PhD Ožbalt Podpečan  Veterinarian medicine  Researcher  2019 - 2024  117 
44.  22770  PhD Blanka Premrov Bajuk  Veterinarian medicine  Researcher  2019 - 2023  40 
45.  30710  PhD Sonja Prpar Mihevc  Neurobiology  Researcher  2019 - 2020  108 
46.  29350  PhD Urška Ravnik Verbič  Veterinarian medicine  Researcher  2019 - 2024  42 
47.  18593  PhD Alenka Seliškar  Veterinarian medicine  Researcher  2019 - 2024  259 
48.  13441  PhD Tomaž Snoj  Veterinarian medicine  Researcher  2019 - 2024  139 
49.  18125  Jasna Šporar    Technical associate  2020 - 2024 
50.  21702  PhD Nataša Šterbenc  Veterinarian medicine  Researcher  2021 - 2024  57 
51.  34286  Nina Šterman    Technical associate  2019 - 2024 
52.  19487  PhD Malan Štrbenc  Veterinarian medicine  Researcher  2023 - 2024  87 
53.  33348  PhD Katerina Tomsič  Veterinarian medicine  Researcher  2021 - 2024  44 
54.  13328  PhD Nataša Tozon  Veterinarian medicine  Researcher  2019 - 2024  385 
55.  51852  PhD Tomaž Trobec  Veterinarian medicine  Researcher  2019 - 2024  16 
56.  13336  PhD Matjaž Uršič  Veterinarian medicine  Researcher  2019 - 2024  79 
57.  18117  PhD Modest Vengušt  Veterinarian medicine  Researcher  2019 - 2024  129 
58.  38143  PhD Metka Voga  Veterinarian medicine  Researcher  2019 - 2024 
59.  13334  PhD Milka Vrecl Fazarinc  Veterinarian medicine  Head  2019 - 2024  269 
60.  08506  PhD Jelka Zabavnik Piano  Veterinarian medicine  Researcher  2019 - 2024  204 
61.  28447  PhD Maja Zakošek Pipan  Veterinarian medicine  Researcher  2019 - 2024  132 
62.  05091  PhD Bojan Zorko  Veterinarian medicine  Retired researcher  2019 - 2024  146 
63.  16244  PhD Petra Zrimšek  Veterinarian medicine  Researcher  2019 - 2024  202 
64.  54713  PhD Jurij Žel  Veterinarian medicine  Researcher  2021 - 2022  29 
65.  54724  Neža Žnidaršič  Veterinarian medicine  Junior researcher  2020 - 2024 
66.  22588  PhD Monika Cecilija Žužek  Veterinarian medicine  Researcher  2019 - 2024  67 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,756 
Abstract
Research program Endocrine, immune and enzymatic responses in healthy and sick animals is aimed to gain knowledge of animal responses in physiological, experimental and disease states from the cellular level to the organism and to translate this knowledge into practice. The proposed program is intended to further develop, upgrade and expand basic, comparative and translational clinical research. Pillar-I encompasses basic studies evaluating the genetic predisposition to certain diseases and comparative morphological analysis of skeletal muscle important for the understanding of cellular mechanisms of muscle tissue formation in relation to meat quality. We will also continue to investigate various membrane receptors including homologues of the human Epstein-Barr virus i.e. the porcine lymphotropic herpesvirus receptors (PLHV 1-3) that are associated with the emergence of lymphoproliferative diseases. Through physiological and toxicological studies, we will continue to study the regulation of fluid dynamics and acid-base balance in the lung capillaries and physiological responses of the animals to an incremental physical load. The effects and mechanisms of natural and synthetic molecules that have a wide preclinical therapeutic potential will also be studied. The focus will be on substances that have anti-acetylcholinesterase activity and on certain extracts of plants containing tannins or thymol. Sexual differentiation studies will include evaluation of sexual dimorphism and the effect of sex hormones in combination with long-term stress exposure on brain function, with an emphasis on behavioral outcomes in adulthood and the effect of neural stem cells transplantation into the hippocampus in mice. Pillar-II is aimed to bridge gap between basic research and clinical practice. We want to emphasize the potential impact of the translational research and our ability to respond to current trends in biomedical research by integrating companion animals and testing capabilities for a range of advanced therapies including stem cell–derived therapy and immunotherapy in the fields of veterinary oncology and dentistry. Pillar-II also encompasses the continuation of oxidative stress research, in particular monitoring the progression of heart failure in dogs and the effect of dietary antioxidant supplementation. Immune response to food containing alternative sources of proteins and the prevalence of canine leishmaniosis in Slovenia and indirectly its potential threat to human health will also be evaluated. Further improvement of semen preservation technology, identification of new biomarkers for prediction of semen quality after storage and noninvasive insemination techniques will contribute to the efficient reproduction in domestic animals.
Significance for science
The main scope of the research group is to carry out cutting-edge basic research that will be fundamental for the advancement of science and to plan/perform the applied research. The results obtained contribute to the advancement of both veterinary medicine and the biomedical field. The results can also be successfully implemented in daily use, i.e., optimization/development of diagnostic and prognostic markers, as well as therapeutic methods and agents. With regard to the reduction of experimental animal use, the evaluation and use of animal models to study naturally occurring diseases (clinical cases) is of utmost importance. These data are also of great value in comparative medicine. The contemporary state of the research field enables us to participate in international research projects and allows us to engage in scientific networking with top scientists and research institutions, as well as leading pharmaceutical companies. These successful international collaborations result in high-profile joint publications, organization of international scientific meetings, the ability to translate basic science into practice, and the opportunity to exchange postgraduate students.
Significance for the country
High quality research that is both published in major international scientific journals and presented at international scientific and professional meetings contributes to the advancement of the veterinary profession and the promotion of Slovenia. Activities are aimed to directly benefit socio-economic development and the general public, including education/trainings, textbooks and manuals for students targeting communities and the general public, analytical testing services in accredited laboratories, and guidelines for the ministries. Specifically, members of the research program are involved in university graduate and postgraduate study, as well as long term education programs as lecturers and supervisors of PhD and graduate students. In this way, they contribute to the quality and improvement of the teaching process and to the popularization of the veterinary profession/research work among graduate students and the general public. The research program also has the ability to implement science into laboratory and clinical practice, as is evident by the number of applied projects that take place outside the funding scheme of Slovenian Research Agency; i.e., implementation of target research and development projects; and regulated tasks for the Ministry of Agriculture, Forestry and Food and other contract work for customers, particularly in the area of reproduction of domestic animals. Both improvements on the existence or the development of new diagnostic, prognostic and therapeutic approaches increase the competency of laboratory testing, the competitiveness of our clinical services, and also contribute to animal welfare. The development of novel diagnostic methods and biotechnological protocols has the potential to lead to patent proposals. Data regarding factors that influence the development of perioperative complications can be used for the development of new protocols for inpatient care, which can benefit both veterinary and human patients. The knowledge obtained can also serve as a basis for guideline preparations regarding animal selection for specific genotypes that can be used in breeding programs, as well as plans of action in case of disease breakout (e.g., transmissible spongiform encephalopathies). A cornerstone in the advancement of agriculture in EU is food safety. The results of our selected studies will be used to prepare guidelines for the development of the future dairy industry in Slovenia to ensure safety of milk and dairy products, with a focus on more conventional dairy. Similarly, studies on the biological characteristics of porcine muscle fibers, specifically the heavy myosin chain-based hypertrophy potential of muscle fibers that affect meat quality, may be used to plan better breeding programs that will select breeds of pigs that can be raised for specific purposes. This may prove the autochthonous pig breed “krškopoljski prašič” to be of superior quality for selected purposes. Additionally, such breed selection together with the creation of a sperm bank of Slovenian autochthonous and endangered animal species is highly relevant for raising public awareness about autochthonous breeds, environmental protection, and the maintenance of biodiversity.
Most important scientific results Interim report
Most important socioeconomically and culturally relevant results Interim report
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