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Projects / Programmes source: ARIS

Endocrine,immune,nervous and enzyme responses in healty and sick animals

Periods
Research activity

Code Science Field Subfield
4.04.00  Biotechnical sciences  Veterinarian medicine   
4.04.01  Biotechnical sciences  Veterinarian medicine  Morphology, physiology and animal reproduction 

Code Science Field
B210  Biomedical sciences  Histology, cytochemistry, histochemistry, tissue culture 

Code Science Field
4.03  Agricultural and Veterinary Sciences  Veterinary science 
Evaluation (rules)
source: COBISS
Researchers (51)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  39086  PhD Neža Adamič  Veterinarian medicine  Junior researcher  2016 - 2018  10 
2.  29835  PhD Tomaž Budefeld  Microbiology and immunology  Researcher  2014 - 2016  92 
3.  17572  PhD Marko Cotman  Veterinarian medicine  Technical associate  2014 - 2018  116 
4.  33148  PhD Maša Čater  Biotechnology  Beginner researcher  2017 - 2018  104 
5.  10445  PhD Nina Čebulj-Kadunc  Veterinarian medicine  Researcher  2014 - 2018  204 
6.  26571  PhD Katerina Čeh  Pharmacy  Researcher  2014 - 2016  34 
7.  10395  PhD Aleksandra Domanjko Petrič  Veterinarian medicine  Researcher  2014 - 2018  260 
8.  07850  PhD Marinka Drobnič-Košorok  Veterinarian medicine  Researcher  2014 - 2017  185 
9.  21400  PhD Vladimira Erjavec  Veterinarian medicine  Researcher  2014 - 2018  151 
10.  09149  PhD Gregor Fazarinc  Veterinarian medicine  Researcher  2014 - 2018  203 
11.  12449  PhD Robert Frangež  Veterinarian medicine  Researcher  2014 - 2018  276 
12.  24348  PhD Neža Grgurevič  Veterinarian medicine  Researcher  2014 - 2018  58 
13.  10913  PhD Vesna Kadunc Kos  Veterinarian medicine  Researcher  2014 - 2018  83 
14.  32334  PhD Jasmina Kerčmar  Metabolic and hormonal disorders  Junior researcher  2014 - 2015  43 
15.  21230  PhD Primož Klinc  Veterinarian medicine  Researcher  2014 - 2018  107 
16.  14881  PhD Igor Klobučar  Veterinarian medicine  Technical associate  2014 - 2017  72 
17.  09654  PhD Silvestra Kobal  Veterinarian medicine  Researcher  2014 - 2018  260 
18.  07439  PhD Marjan Kosec  Veterinarian medicine  Researcher  2014 - 2018  387 
19.  14194  PhD Tina Kotnik  Veterinarian medicine  Researcher  2014 - 2018  141 
20.  35346  Katja Kozinc Klenovšek  Veterinarian medicine  Junior researcher  2014 - 2016 
21.  20042  PhD Petra Kramarič  Veterinarian medicine  Researcher  2014 - 2018  59 
22.  15198  PhD Peter Kruljc  Veterinarian medicine  Researcher  2014 - 2018  129 
23.  23485  PhD Valentina Kubale Dvojmoč  Veterinarian medicine  Researcher  2014 - 2018  271 
24.  21402  PhD Barbara Lukanc  Veterinarian medicine  Researcher  2014 - 2018  68 
25.  13330  PhD Gregor Majdič  Veterinarian medicine  Researcher  2014 - 2018  576 
26.  50524  PhD Maša Mavri  Veterinarian medicine  Junior researcher  2017 - 2018  32 
27.  39087  PhD Nina Milevoj  Veterinarian medicine  Junior researcher  2016 - 2018  54 
28.  10253  PhD Janko Mrkun  Veterinarian medicine  Researcher  2014 - 2018  270 
29.  25587  PhD Ana Nemec  Veterinarian medicine  Researcher  2014 - 2018  321 
30.  16308  PhD Alenka Nemec Svete  Veterinarian medicine  Researcher  2014 - 2018  212 
31.  07516  PhD Zlatko Pavlica  Veterinarian medicine  Researcher  2014 - 2018  376 
32.  24507  PhD Darja Pavlin  Veterinarian medicine  Researcher  2014 - 2018  160 
33.  25588  PhD Tanja Plavec  Veterinarian medicine  Researcher  2014 - 2018  132 
34.  33619  PhD Ožbalt Podpečan  Veterinarian medicine  Researcher  2014 - 2018  117 
35.  22770  PhD Blanka Premrov Bajuk  Veterinarian medicine  Researcher  2014 - 2018  40 
36.  30710  PhD Sonja Prpar Mihevc  Neurobiology  Beginner researcher  2017 - 2018  108 
37.  29350  PhD Urška Ravnik Verbič  Veterinarian medicine  Researcher  2014 - 2018  42 
38.  18593  PhD Alenka Seliškar  Veterinarian medicine  Researcher  2014 - 2018  257 
39.  13441  PhD Tomaž Snoj  Veterinarian medicine  Researcher  2014 - 2018  139 
40.  29351  PhD Tanja Španić  Veterinarian medicine  Researcher  2014 - 2016  42 
41.  13328  PhD Nataša Tozon  Veterinarian medicine  Researcher  2014 - 2018  383 
42.  51852  PhD Tomaž Trobec  Veterinarian medicine  Junior researcher  2018  15 
43.  13336  PhD Matjaž Uršič  Veterinarian medicine  Researcher  2014 - 2018  79 
44.  18117  PhD Modest Vengušt  Veterinarian medicine  Researcher  2014 - 2018  129 
45.  38143  PhD Metka Voga  Veterinarian medicine  Junior researcher  2015 - 2018 
46.  13334  PhD Milka Vrecl Fazarinc  Veterinarian medicine  Head  2014 - 2018  266 
47.  08506  PhD Jelka Zabavnik Piano  Veterinarian medicine  Researcher  2014 - 2018  204 
48.  28447  PhD Maja Zakošek Pipan  Veterinarian medicine  Researcher  2014 - 2018  131 
49.  05091  PhD Bojan Zorko  Veterinarian medicine  Researcher  2014 - 2018  146 
50.  16244  PhD Petra Zrimšek  Veterinarian medicine  Researcher  2014 - 2018  202 
51.  22588  PhD Monika Cecilija Žužek  Veterinarian medicine  Researcher  2014 - 2018  66 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,689 
Abstract
The aim of the research program »Endocrine, immune and enzyme responses in healthy and sick animals« is to provide basic knowledge on host response during physiologic, experimental and pathologic conditions from the cell to the whole body level. The ultimate goal is to implement this knowledge in development of novel diagnostic, prognostic and treatment protocols and methods. Clinical periodontology studies suggest individual variations in systemic host response, and possible causes for the differences observed will be studied to provide individually-tailored approach to these patients. Further studies on the dynamic of changes in antioxidant stress markers during health and disease will evaluate the effect of antioxidant food supplements. Inflammatory and antioxidant stress markers will be assessed as markers of progression of cardiovascular diseases in dogs. Volume and ionic balance in the pulmonary circulation of horses will also be studied. Lipid mobilisation syndrome during period of negative energy balance after parturition in dairy cows, developmental potential of oocytes and functionality of bull spermatozoa will be related to the metabolic and oxidative stress induced by seasonal heat, as genetic selection for high milk yield decreases the thermoregulatory ability in animals. Improvement of semen preservation technology and identification of new biomarkers for prediction of semen quality after storage will lead to improved fertility outcome of domestic animals. Studies will also include the evaluation of antiectoparasitics in chronic stress prevention in grazing animals and the dynamics of steroid hormone release in milk and their intestinal absorption. Comparative morphology and genetic analyses of porcine skeletal muscles will be employed to assess biological characteristics of muscles in relation to the meat quality and processing suitability for selected meat products. Genetic predisposition to certain diseases will also be studied. The mechanism of action of natural and synthetic molecules, which have anticholinesterase activity or specifically block nicotinic acetylcholine receptors, will be evaluated in vitro and in vivo and their preclinical potential assessed. Sexual differentiation studies will include evaluation of sexual dimorphism and the effect of sex hormones in combination with stress exposure on brain development/function. In the field of membrane receptors research will be focused on gender-specific differences in the activation of secondary messenger system and possible involvement of distinct arrestins. Electrogene therapy will be further employed in a clinical setting, providing important data in translational oncology. The research will be expanded to study immune mechanisms involved in tumor progression and to evaluate the potential for novel immunotherapy approaches. Extensive studies will also be performed in the field of stem cell use.
Significance for science
The main scope of the research group is to carry out cutting-edge basic research that is fundamental for the advancement of science and for planning/performing the applied research. The results obtained contribute to the advancement of veterinary medicine and biomedical field. They are also successfully implemented into daily clinical use i.e. optimization/development of diagnostic and prognostic markers as well as therapeutic methods and agents. In view of reduction of experimental animals use, evaluation and use of animal models of naturally occurring diseases (clinical cases) is of utmost importance. This data are also of great value in comparative medicine. Contemporary state of the research topics enable us to participate in the international research projects, scientific networks with top scientists and research institutions as well as leading pharmaceutical companies. The results of successful international collaboration are high-profile joint publications, organization of international scientific meetings, the ability to translate basic science into practice and the possibility to exchange postgraduate students.
Significance for the country
High quality research published in major international scientific journals and presented at the international scientific and professional meetings contributes to the advancement of veterinary profession and promotion of Slovenia. Members of the research program group are involved in the university graduate and postgraduate study programs as professors and supervisors of PhD and graduate students. In this way, they contribute to the quality and improvement of the teaching process and to the popularization of research work among graduate students. Research program group has also the ability to implement science into clinical practice as evident from the number of applied projects that take place outside the funding scheme of Slovenia Research Agency i.e. implementation of target research and development projects and regulated tasks for the Ministry of Agriculture, Forestry and Food and other contract work for customers, particularly in the area of reproduction of domestic animals. Improvement of existing or development of new diagnostic, prognostic and therapeutic approaches increase the competitiveness of our clinical services and contribute to animal welfare. Development of novel diagnostic methods and biotechnology protocols has the potential of patent proposals. Data about factors influencing perioperative complications development can be used in development of new protocols for inpatients care that can benefit veterinary as well as human patients. Knowledge obtained can also serve as basis for guidelines preparation on animal selection towards specific genotypes, that can be used in breeding programs and action plans in case of disease breakout (e.g. transmissible spongiform encephalopathies). Similarly, data on biologic characteristics of porcine muscle fibers, and specifically heavy miosyn chain-based hyperthrophy potential of muscle fibers that affect meat quality, may be used to better plan breeding programs towards selected breeds of pigs that can be raised for specific purposes. This may prove the autochthonous pig breed “krškopoljski prašič” to be of superior quality for selected purposes. Additionally, such breed selection is important in raising public awareness about autochthonous breeds and environment protection.
Most important scientific results Annual report 2014, 2015, final report
Most important socioeconomically and culturally relevant results Annual report 2014, 2015, final report
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